Paradigm shift: semantic memory decline as a biomarker of preclinical Alzheimer's disease

Paradigm shift: semantic memory decline as a biomarker of preclinical Alzheimer's disease.

Subtle Cognitive Decline and Biomarker Staging in Preclinical Alzheimer's Disease.

The NIA-AA criteria for "preclinical" Alzheimer's disease (AD) propose a staging method in which AD biomarkers follow an invariable temporal sequence in accordance with the amyloid cascade hypothesis. However, recent findings do not align with the proposed temporal sequence and "subtle cognitive decline," which has not been definitively operationalized, may occur earlier than suggested in precl...

Role of microRNA as a biomarker in Alzheimer’s disease

Introduction: MicroRNAs are small, non-coding, and protected RNA molecules that regulate gene expression after transcription by mRNA degradation or inhibition of protein synthesis. The function of these molecules is critical to many cellular processes, including growth, development, differentiation, homeostasis, apoptosis, aging, stress resistance. In addition, some diseases including cancer, a...

Functional magnetic resonance imaging of semantic memory as a presymptomatic biomarker of Alzheimer's disease risk.

Extensive research efforts have been directed toward strategies for predicting risk of developing Alzheimer's disease (AD) prior to the appearance of observable symptoms. Existing approaches for early detection of AD vary in terms of their efficacy, invasiveness, and ease of implementation. Several non-invasive magnetic resonance imaging strategies have been developed for predicting decline in ...

In-Memory Database Systems - A Paradigm Shift

In today’s world, organizations like Google, Yahoo, Amazon, Facebook etc. are facing drastic increase in data. This leads to the problem of capturing, storing, managing and analyzing terabytes or petabytes of data, stored in multiple formats, from different internal and external sources. Moreover, new applications scenarios like weather forecasting, trading, artificial intelligence etc. need hu...